Klinične raziskave na področju manuka medu

 

Identifikacija in kvantitativna določitev 2 – acetil – 1 -pirolina v Manuka medu (Leptospermum scoparium).
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Manuka med in Staphylococcus aureus
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Identifikacija in kvantifikacija metilglioksala v Manuka medu
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Manuka med in bakterijcidnost proti Pseudomonas aeruginosa
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Izboljšanje antibiotijske aktivnosti Manuka medu pri ranah
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In vitro učinek Manuka medu na rast ustnih bakterij
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Več kot 300 kliničnih raziskav manuka medu in MGO lahko najdete na spodnjih povezavah:

https://www.ncbi.nlm.nih.gov/pubmed/?term=honey+mgo

https://www.ncbi.nlm.nih.gov/pubmed/?term=Manuka+honey

Oskrba sindorma diabetične noge z manuka medom – PA in MRSA – case study
Zerm_Poster_Manukahonig_Treatment of diabetic foot syndrom with Manuka Honey
Zerm_Manuka Diabetic Foot Syndrom

Frame K, Cheung IMY, Wang MTM, Turnbull PR, Watters GA, Craig JP.
Comparing the in vitro effects of MGO Manuka honey and tea tree oil on ocular Demodex viability. Cont Lens Anterior Eye. 2018 Dec;41(6):527-530. doi: 10.1016/j.clae.2018.06.006. Epub 2018 Jul 7.

 

Hayes G, Wright N, Gardner SL, Telzrow CL, Wommack AJ, Vigueira PA. Manuka honey and methylglyoxal increase the sensitivity of Staphylococcus aureus to linezolid. Lett Appl Microbiol. 2018 Jun;66(6):491-495. doi: 10.1111/lam.12880. Epub 2018 Apr 19.

 

Deng J, Liu R, Lu Q, Hao P, Xu A, Zhang J, Tan J. Biochemical properties, antibacterial and cellular antioxidant activities of buckwheat honeyin comparison to manuka honey. Food Chem. 2018 Jun 30;252:243-249. doi: 10.1016/j.foodchem.2018.01.115. Epub 2018 Jan 20.

 

Craig JP, Wang MTM, Ganesalingam K, Rupenthal ID, Swift S, Loh CS, Te Weehi L, Cheung IMY, Watters GA. Randomised masked trial of the clinical safety and tolerability of MGO Manuka Honey eye cream for the management of blepharitis. BMJ Open Ophthalmol. 2017 Aug 4;1(1):e000066. doi: 10.1136/bmjophth-2016-000066. eCollection 2017.

PMID: 29354710 Free PMC Article

 

Craig JP, Rupenthal ID, Seyfoddin A, Cheung IMY, Uy B, Wang MTM, Watters GA, Swift S. Preclinical development of MGO Manuka Honey microemulsion for blepharitis management. BMJ Open Ophthalmol. 2017 Aug 7;1(1):e000065. doi: 10.1136/bmjophth-2016-000065. eCollection 2017.

PMID: 29354709 Free PMC Article

 

Niaz K, Maqbool F, Bahadar H, Abdollahi M. Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration. Curr Drug Metab. 2017;18(10):881-892. doi: 10.2174/1389200218666170911152240. Review.

 

Bulman SEL, Tronci G, Goswami P, Carr C, Russell SJ. Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal.

Materials (Basel). 2017 Aug 16;10(8). pii: E954. doi: 10.3390/ma10080954.

PMID:28813014 Free PMC Article

 

Rückriemen J, Hohmann C, Hellwig M, Henle T. Unique fluorescence and high-molecular weight characteristics of protein isolates from manuka honey (Leptospermum scoparium). Food Res Int. 2017 Sep;99(Pt 1):469-475. doi: 10.1016/j.foodres.2017.06.011. Epub 2017 Jun 4.

 

Grainger MNC, Owens A, Manley-Harris M, Lane JR, Field RJ. Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part IV – Formation of HMF. Food Chem. 2017 Oct 1;232:648-655. doi: 10.1016/j.foodchem.2017.04.066. Epub 2017 Apr 13.

 

Hellwig M, Rückriemen J, Sandner D, Henle T. Unique Pattern of Protein-Bound Maillard Reaction Products in Manuka (Leptospermum scoparium) Honey.

J Agric Food Chem. 2017 May 3;65(17):3532-3540. doi: 10.1021/acs.jafc.7b00797. Epub 2017 Apr 24.

 

Rückriemen J, Klemm O, Henle T. Manuka honey (Leptospermum scoparium) inhibits jack bean urease activity due to methylglyoxal and dihydroxyacetone. Food Chem. 2017 Sep 1;230:540-546. doi: 10.1016/j.foodchem.2017.03.075. Epub 2017 Mar 15.

 

Cokcetin NN, Pappalardo M, Campbell LT, Brooks P, Carter DA, Blair SE, Harry EJ. The Antibacterial Activity of Australian Leptospermum Honey Correlates with Methylglyoxal Levels. PLoS One. 2016 Dec 28;11(12):e0167780. doi: 10.1371/journal.pone.0167780. eCollection 2016.

PMID: 28030589 Free PMC Article

 

Tenci M, Rossi S, Bonferoni MC, Sandri G, Mentori I, Boselli C, Cornaglia AI, Daglia M, Marchese A, Caramella C, Ferrari F. Application of DoE approach in the development of mini-capsules, based on biopolymers and manuka honey polar fraction, as powder formulation for the treatment of skin ulcers. Int J Pharm. 2017 Jan 10;516(1-2):266-277. doi: 10.1016/j.ijpharm.2016.10.050. Epub 2016 Oct 24.

 

Spiteri M, Rogers KM, Jamin E, Thomas F, Guyader S, Lees M, Rutledge DN. Combination of 1H NMR and chemometrics to discriminate manuka honey from other floral honey types from Oceania.

Food Chem. 2017 Feb 15;217:766-772. doi: 10.1016/j.foodchem.2016.09.027. Epub 2016 Sep 7.

 

Rabie E, Serem JC, Oberholzer HM, Gaspar AR, Bester MJ. How methylglyoxal kills bacteria: An ultrastructural study. Ultrastruct Pathol. 2016;40(2):107-11. doi: 10.3109/01913123.2016.1154914. Epub 2016 Mar 17.

 


Mannina L, Sobolev AP, Coppo E, Di Lorenzo A, Nabavi SM, Marchese A, Daglia M. Antistaphylococcal activity and metabolite profiling of manuka honey (Leptospermum scoparium L.) after in vitro simulated digestion.
Food Funct. 2016 Mar;7(3):1664-70. doi: 10.1039/c5fo01409c.

 

Charyasriwong S, Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N.

In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection. Arch Med Res. 2015 Jan;46(1):8-16. doi: 10.1016/j.arcmed.2014.12.002. Epub 2014 Dec 15.

 

Grainger MN, Manley-Harris M, Fauzi NA, Farid MM. Effect of high pressure processing on the conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka (Leptospermum scoparium) honey and models thereof.

Food Chem. 2014 Jun 15;153:134-9. doi: 10.1016/j.foodchem.2013.12.017. Epub 2013 Dec 10.

 

Rogers KM, Grainger M, Manley-Harris M. The unique manuka effect: why New Zealand manuka honey fails the AOAC 998.12 C-4 sugar method. J Agric Food Chem. 2014 Mar 26;62(12):2615-22. doi: 10.1021/jf404767b. Epub 2014 Mar 18.

 

Paramasivan S, Drilling AJ, Jardeleza C, Jervis-Bardy J, Vreugde S, Wormald PJ. Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model. Int Forum Allergy Rhinol. 2014 Mar;4(3):187-95. doi: 10.1002/alr.21264. Epub 2014 Jan 10.

 

Majtan J, Bohova J, Prochazka E, Klaudiny J. Methylglyoxal may affect hydrogen peroxide accumulation in manuka honey through the inhibition of glucose oxidase. J Med Food. 2014 Feb;17(2):290-3. doi: 10.1089/jmf.2012.0201. Epub 2013 Nov 5.

PMID: 24192110 Free PMC Article

 

Daglia M, Ferrari D, Collina S, Curti V. Influence of in vitro simulated gastroduodenal digestion on methylglyoxal concentration of Manuka ( Lectospermum scoparium ) honey. J Agric Food Chem. 2013 Mar 6;61(9):2140-5. doi: 10.1021/jf304299d. Epub 2013 Feb 25.

 

Atrott J, Haberlau S, Henle T. Studies on the formation of methylglyoxal from dihydroxyacetone in Manuka(Leptospermum scoparium) honey.

Carbohydr Res. 2012 Nov 1;361:7-11. doi: 10.1016/j.carres.2012.07.025. Epub 2012 Aug 8.

 

Majtan J, Klaudiny J, Bohova J, Kohutova L, Dzurova M, Sediva M, Bartosova M, Majtan V.

Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: Possible therapeutic implications. Fitoterapia. 2012 Jun;83(4):671-7. doi: 10.1016/j.fitote.2012.02.002. Epub 2012 Feb 17.

 

Kilty SJ, Duval M, Chan FT, Ferris W, Slinger R. Methylglyoxal: (active agent of manuka honey) in vitro activity against bacterial biofilms. Int Forum Allergy Rhinol. 2011 Sep-Oct;1(5):348-50. doi: 10.1002/alr.20073. Epub 2011 May 25.

 

Jervis-Bardy J, Foreman A, Bray S, Tan L, Wormald PJ. Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope. 2011 May;121(5):1104-7. doi: 10.1002/lary.21717.

 

Mavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand.

Mol Nutr Food Res. 2008 Apr;52(4):483-9. doi: 10.1002/mnfr.200700282.